Figure 8
From: Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections
Ectopic distribution of reelin in vldlr−/−; lrp8−/−mutant LGN. Reelin distribution was assessed by immunostaining (A) P3 control and (B,C) vldlr−/−;lrp8−/− mutant (DKO) LGN. Insets show high magnification images of the areas indicated by boxes. Note in (B,C), the presence of reelin-immunoreactivity in the dorsomedial pole of DKO mutant dLGN. For all images, the outline of the dLGN is depicted with white dots. dLGN are labeled ‘d’, vLGN are labeled ‘v’ and arrows indicate IGL. Scale bar = 180 μm for (A to F) and 50 μm for insets. DKO, double knockout; dLGN, dorsal LGN; IGL, intergeniculate leaflet; LGN, lateral geniculate nucleus; vLGN, ventral LGN.