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Figure 1 | Neural Development

Figure 1

From: Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections

Figure 1

Retinogeniculate projections in wild-type, relnrl/rl, vldlr−/−and lrp8−/−mice. Retinogeniculate projections in (A) P14 controls, (B) P14 relnrl/rl mutants, (C) P13 vldlr−/− mutants and (D) P13 lrp8−/− mutants were labeled by intraocular injection of fluorescently conjugated CTB. Left eyes were injected with Alexa Fluor 594 CTB and right eyes were injected with Alexa Fluor 488 CTB. LGN from right hemispheres are shown. In P14 relnrl/rl mutants (B), note the near absence of retinal projections to the IGL, and the bundle of labeled retinal axons extending out of the LGN and into non-retino-recipient thalamus (arrowheads). ‘Contra’ denotes projections originating from the contralateral retina and ‘ipsi’ denotes projections originating from the ipsilateral retina. dLGN are labeled ‘d’, vLGN are labeled ‘v’ and arrows indicate IGL. The color of the label in panels (A to D) and (A’ to D’) indicates the color of the image shown in (A” to D”). Scale bar = 200 μm. CTB, cholera toxin B subunit; dLGN, dorsal LGN; IGL, intergeniculate leaflet; LGN, lateral geniculate nucleus; vLGN, ventral LGN.

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