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Figure 1 | Neural Development

Figure 1

From: Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions

Figure 1

The dynamic expression pattern of Shh in the hypothalamic primordium. (A-H) RNA in situ hybridization in whole mounts (A1-A3) or on transverse sections of the hypothalamic primordium (hyp) at several anterior-posterior levels (B-H4). Shh is initially expressed in the ventral midline in the posterior hyp at E8.5 (black arrows in A1-A3; B-F). Shh expression expands laterally over the subsequent days of development and starts to be downregulated in the ventral midline (E9.5 to E12.5) (A1-H4). At E9.5 to E12.5 Shh is also expressed in the preoptic area and the zona limitans intrathalamica (zli). Red arrowheads in (A2, A3) indicate the preoptic area, and asterisks indicate the zli. Insets in (C1, D2): higher magnifications of the boxed area. Mb, midbrain; MM, mammillary primordium. Scale bars: 80 μm (B-F); 200 μm (A1-A3, B1-H4).

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