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Table 1 Gain of Mdka function does not advance cell cycle exit

From: Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina

  Average number of cells/section at 34 hpf EdU-negative cells at 48 hpf (n) Proportion of EdU-negative cells at 48 hpf
Untreated 156 ± 22 53 ± 10 0.34 ± 0.09
Mdka l-o-f 138 ± 19 2 ± 2 0.02 ± 0.02a
WT 147 ± 23 51 ± 38 0.34 ± 0.17
Mdka g-o-f 191 ± 32 71 ± 28 0.38 ± 0.08
  1. For each group, half the embryos were sacrificed at 34 hpf for cell counts. The remaining embryos were injected with EdU every 6 h starting at 34 hpf and fixed at 48 hpf. EdU-negative cells counted at 48 hpf were those that had exited cell cycle by 34 hpf. The proportion of EdU-negative cells was not significantly different between the untreated, WT, and Mdka g-o-f groups. The proportion of post-mitotic cells in the Mdka l-o-f group was significantly smaller than in controls. g-o-f, gain-of-function; l-o-f, loss-of-function. aP <0.05.