Figure 5
From: Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system
Treatment with Eph receptor fusion protein results in increased targeting errors and atypical NL morphology. (A-D) RDA tracings of contralateral-projecting NM axons at E10 in untreated embryos (A) or embryos treated during E6 to E9 with IgG-Fc control (B), EphB1-Fc (C), or EphA4-Fc (D). Axonal processes inappropriately cross the NL cell body layer, terminating in the dorsal NL neuropil in embryos treated with EphB1-Fc or EphA4-Fc (white arrows, C, D). (E) Quantification of mean axon targeting errors and (F) percentage of embryos with an atypical NL (including either atypical NL morphology or atypical NL border or both). Scale bar = 25 μm.