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Figure 7 | Neural Development

Figure 7

From: Neurog1 and Neurog2 coordinately regulate development of the olfactory system

Figure 7

Neuronal misspecification defects in Neurog2−/−olfactory bulbs and Neurog1/2−/−olfactory bulb-like structures. (A) to (L) Co-immunostaining of GFP (green, A to L) with Sp8 (red, A to D), Pax6 (red, E to H) or Er81 (red, I to L) in E18.5 wild-type, (A,E,I), Neurog1−/− (B,F,J), Neurog2KI/KI (C,G,K), and Neurog1/2−/− (D,H,L) OBs. Insets to the right of each panel are fourfold magnifications of boxed areas. (M) to (O) Quantitation of total Sp8+GFP+ cells (M), Pax6+GFP+ cells (N), and Er81+GFP+ cells (O) in embryonic day 18.5 wild-type, Neurog1−/−, Neurog2KI/KI and Neurog1/2−/− OBs. *P <0.05, **P <0.01, ***P <0.005. GCL, granule cell layer; GL, glomerular layer; MCL, mitral cell layer; VZ, ventricular zone. Scale bars: 500 μm (A) to (L).

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