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Figure 3 | Neural Development

Figure 3

From: Distinct perinatal features of the hyperpolarization-activated non-selective cation current Ih in the rat cortical plate

Figure 3

Activation kinetics of pharmacologically isolated I h slightly accelerated with age. (A) Representative Ih activation traces of P0, P1 and P30 neurons in response to hyperpolarizing step potentials of −110 mV and −120 mV (voltage protocol: bottom right). The traces are depicted from approximately 20 milliseconds after step onset (skipping the capacitive relaxation) to the end of the 2-second step. Red lines are double exponential fits. Note that current amplitudes have been normalized for comparability. (B) Activation time constants speeded up only marginally from P0 to P30, when measured somatically. Displayed are fast (circles) and slow (squares) time constants of a double exponential fit. Ages in (B) and (C) are coded in colors: blue - P0, red - P1, black - P30. (C) Population data and 25 to 75% box plots on the amplitude contribution of fast-activating Ih components to the whole current (n = 8 - 9) for the studied time points. Solid lines through boxes and data represent means.

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