Figure 5
From: Normal sulfation levels regulate spinal cord neural precursor cell proliferation and differentiation
Sodium chlorate increases Erk1/2 activation levels in primary neurospheres. (A) Treatment of primary neurospheres grown either in the presence of EGF and FGF2 or FGF2 alone with NaClO3 reduced the expression level of the sulfation-dependent 473HD epitope. (B) In contrast, the phosphorylation of Erk1/2 (pErk1/2) was enhanced in response to NaClO3. However, NaClO3 did not affect the phosphorylation of Akt (pAkt), another downstream effector molecule of tyrosine kinase receptors. (C) In line with an enhanced spontaneous neuronal differentiation, the expression level of the EGFR was also reduced.