Figure 5
From: Midline crossing is not required for subsequent pathfinding decisions in commissural neurons
Sequential roles for dcc , robo3 , and robo2 in CoPA pathfinding. A CoPA utilizes DCC in order to navigate to the midline, through Netrin attraction, and inhibition of Robo2. B Once CoPA growth cones enter the ventral zone of the spinal cord, they require both Robo3 and DCC activity to penetrate the midline. C The formation of the ventral commissure in the spinal cord is determined through robo2 and robo3. D Postcrossing dorsal growth is dependent on robo2 activity.