TY - JOUR AU - Knott, Thomas K. AU - Madany, Pasil A. AU - Faden, Ashley A. AU - Xu, Mei AU - Strotmann, Jörg AU - Henion, Timothy R. AU - Schwarting, Gerald A. PY - 2012 DA - 2012/05/04 TI - Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance JO - Neural Development SP - 17 VL - 7 IS - 1 AB - The defining feature of the main olfactory system in mice is that each olfactory sensory neuron expresses only one of more than a thousand different odorant receptor genes. Axons expressing the same odorant receptor converge onto a small number of targets in the olfactory bulb such that each glomerulus is made up of axon terminals expressing just one odorant receptor. It is thought that this precision in axon targeting is required to maintain highly refined odor discrimination. We previously showed that β3GnT2−/− mice have severe developmental and axon guidance defects. The phenotype of these mice is similar to adenylyl cyclase 3 (AC3) knockout mice largely due to the significant down-regulation of AC3 activity in β3GnT2−/− neurons. SN - 1749-8104 UR - https://doi.org/10.1186/1749-8104-7-17 DO - 10.1186/1749-8104-7-17 ID - Knott2012 ER -