Figure 4

Comparison of amino acid sequences of mature BMPs. Murine (m) sequences are aligned beginning two amino acids upstream from the first conserved cysteine of the mature region [10] and numbered along the top according to BMP7 sequence. Numbering corresponding to individual BMPs is shown to the left of each sequence. (A) Comparison of BMP6 with BMP7 and BMP5. Bold red letters in BMP6 and BMP7 indicate non-conservative amino acid differences. Orange letters in BMP5 indicate residues that are the same as those in BMP7. Green letters in BMP5 represent residues the same as those found in BMP6. (B) Comparison of BMP6 with other BMPs that orient: BMP7, BMP2, BMP4 and BMP9. Arrows indicate amino acid residues (36, 48, 65, 98 (BMP7 numbering)) that are unique in BMP6. Each of the other four amino acid differences in BMP6 is shared by at least one other BMP with orienting activity (indicated by green boxes). At position 36, the residues in BMP2 and BMP9 (green boxes) represent a conservative substitution from that in BMP6.