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Figure 8 | Neural Development

Figure 8

From: The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting

Figure 8

dom and E(Pc) mutants cause derepression of a PN-GAL4. (A, B) dom-/-GH146-labeled anterodorsal (A) and lateral (B) neuroblast clones show a mild reduction in cell number and disorganization of dendrite targeting. (C) dom-/-GH146-labeled ventral neuroblast clones show a mild reduction in dendrite elaboration. (D, E) dom-/-Mz19-labeled anterodorsal (D) and lateral (E) neuroblast clones ectopically mark a large number of PNs targeting to many glomeruli. (F) dom-/-Mz19-labeled neuroblast clones ectopically mark ventral cells targeting to a number of glomeruli. (G, H) dom-/-Mz19 ectopically labels single cell clones, which target dendrites to both DA4l (G1) and DL1 (G2), with an L-shaped axon pattern in the lateral horn (H). (I-P) Equivalent experiments to (A-H) using E(Pc) mutants. E(Pc)-/-GH146 and MZ19 clones show similar phenotypes to dom-/-clones. Green marks mCD8-GFP-labeled PNs generated by MARCM and labeled using GH146-GAL4 or Mz19-GAL4. (G, O) show partial confocal stacks; (A-F, H-N, P) show full confocal stacks; magenta is the presynaptic marker nc82; symbols are as in Figure 2. Scale bars: 20 μm in (A) (for A-G, I-O) and (H) (for H, P).

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