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Figure 6 | Neural Development

Figure 6

From: The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting

Figure 6

dom mutants yield similar phenotypes to Bap55 mutants. (A, B) dom-/-DL1 PNs mistarget their dendrites to the anterior glomerulus DA4l (A1). dom-/-DL1 PNs retain part of their dendritic mass in the posterior glomerulus DL1 (A2). They maintain their L-shaped axon pattern in the lateral horn and branches in the mushroom body calyx (B). (C, D) Expression of UAS-Bap55 in a dom-/-DL1 PN cannot suppress the dendrite mistargeting phenotype. Dendrites maintain mass in both DA4l (C1) and DL1 (C2). The axon also maintains its L-shaped pattern (D). (E) Quantification of mistargeting phenotypes for (A, C). Green marks mCD8-GFP-labeled PNs generated by MARCM and labeled using GH146-GAL4. (A, C) show partial confocal stacks; (B, D) show full confocal stacks; magenta is the presynaptic marker nc82; symbols are as in Figure 2. Scale bars: 20 μm in (A) (for A, C) and (B) (for B, D).

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