Figure 5

Expression of YFP-NLG2 does not significantly alter the spontaneous inhibitory drive onto retinal ganglion cells. (A) Example traces showing sIPSCs from whole-cell recordings of wild-type retinas (WT; cells 1 and 2) and YFP-NLG2-expressing retinas (cells 3 and 4) at P21 (inset magnifications showing individual events). (B) Mean frequencies and median amplitudes of sIPSCS from WT RGCs (open-triangles, n = 6 cells), and YFP-NLG2-expressing RGCs (open-circles, n = 7 cells). The differences in means between each group (dark grey symols) were not statistically different (frequency P = 0.23, amplitude P = 0.23, Wilcoxon Rank-sum test). Values for the example traces shown in (A) are indicated by the numbers 1 to 4 (light grey symbols). Error bars are standard error of the means.