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Figure 4 | Neural Development

Figure 4

From: Neuronal migration defects in the Loa dynein mutant mouse

Figure 4

In utero electroporation assay exposes a two-day migratory delay in the Loa/Loa mice. (A,B) Coronal sections of a wild-type (A) or Loa/Loa (B) mouse brain 3, 4, or 5 days after electroporation at E15 with GFP cDNA. In the wild-type brain (A), GFP-positive neurons migrated radially from the ventricular zone (VZ) to cortical plate (CP) with increasing time, while in the Loa/Loa brain (B), GFP-positive neurons migrated more slowly and did not reach the CP until day 5. Scale bar = 100 μm. (C) Percentage of GFP-positive cells in different regions of the neocortex in wild-type and Loa/Loa brains. Error bars represent the standard deviation. At least three mutant brains and three littermate control brains were analyzed at each day after electroporation. CP, cortical plate; IZ, intermediate zone; SVZ, subventricular zone; VZ, ventricular zone.

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