Figure 3
From: Neuronal migration defects in the Loa dynein mutant mouse
BrdU birthdating study reveals defects in neuronal migration in the Loa/Loa mutants. (A,B) Pregnant mice were injected with BrdU at either E16 (A) or E18 (B), and wild-type and Loa/Loa littermates were sacrificed at P0. (A) Migration of E16 BrdU-labeled neurons in wild-type and Loa/Loa brain slices reveals a delay in migration for the Loa/Loa neurons, which is quantified in the graph below (mean density of BrdU-positive cells ± standard deviation). (B) Migration of E18 BrdU-labeled neurons in wild-type and Loa/Loa brain slices reveals a delay in migration for the Loa/Loa neurons, which is quantified in the graph below (mean density of BrdU-positive cells ± standard deviation). Scale bar = 200 μm.