Figure 2
From: Neuronal migration defects in the Loa dynein mutant mouse
Loa mutant mouse brains exhibit a delay in hippocampal radial migration. (A) P0 brain slices stained with DAPI reveal a normal hippocampal structure, but a smaller dentate gyrus in the Loa/Loa compared with wild-type brains. (B) Embryonic day (E) 16, E18 and P0 brains were stained with Prox-1, a marker for granule neurons that migrate to form the dentate gyrus of the hippocampus. The progression of Prox-1-labeled neurons is delayed in the Loa/Loa brain compared with the wild-type brain. Scale bars = 200 μm.