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Figure 6 | Neural Development

Figure 6

From: Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling

Figure 6

dPax and Pros control the neuronal to non-neuronal switch in the R7 equivalence group. (A-D) In eyes overexpressing Pros in the absence of dPax2 (sev> Pros; spapoleyes), lenses are almost absent by SEM (A,B), no Cut-positive CCs are observed (C, green), and R7 number is significantly increased, with three to four often present in individual ommatidia (D, circles). (E-H) In eyes overexpressing dPax2 in the absence of Pros (sev> dPax2+prosRNAieyes), lens formation is mildly disrupted (E,F), an average of five CCs/ommatidia are formed (G, circles), and R7 PRs are rarely observed (H). (I) Quantification of PR (magenta) and CC (green) numbers in pros and dPax2 LOF and GOF experiments (see Table 1 for values, and Materials and methods for specific genotypes). Error bars represent standard deviation

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