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Figure 11 | Neural Development

Figure 11

From: 5-HT receptors mediate lineage-dependent effects of serotonin on adult neurogenesis in Procambarus clarkii

Figure 11

Pharmacological treatment of serotonin receptors. (A) Dose-response curve for the 5-HT1α agonist quipazine maleate salt (QMS) and levels of BrdU incorporation in cells in the LPZ of the crayfish brain. The graph of mean BrdU-labeled cell counts versus QMS concentrations (10-11 to 10-5 M) demonstrates that the rate of cell proliferation in cluster 10 is increased after QMS treatment. One-way ANOVA followed by Tukey multiple comparison (P < 0.05) reveals significant differences at QMS levels of 10-9 M relative to control brains. n = number of cluster 10s per group. (B) QMS does not alter the number of BrdU-labeled cells in the niches and migratory streams in the brains of treated crayfish relative to untreated controls. (C) Dose-response curve for the 5-HT2β antagonist methiothepin mesylate salt (MMS) and levels of adult neurogenesis in the LPZ of crayfish brains. The graph of BrdU-labeled cell counts versus MMS concentrations (10-10 to 10-4 M) demonstrates that the rate of cell proliferation in cluster 10 is decreased after blocking the function of 5-HT2β with MMS. One-way ANOVA followed by Tukey multiple comparison (P < 0.05) reveals significant differences at MMS concentrations of 10-5 to 10-9 M relative to control brains. n = number of cluster 10s per group. Same letter notation on the histograms indicates that there are no statistical differences among the groups; different letters indicate statistical significance. (D) MMS does not alter the number of BrdU-labeled cells in the niches and migratory streams in the brains of treated crayfish relative to untreated controls. Error bars represent standard error of the mean.

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