Figure 7

Reduced numbers of TrkA⁺and TrkB⁺neurons in Rbpj -deficient DRG. (A-P) SCG10 (A,B,I,J), TrkA (C,D,K,L), TrkB (E,F,M,N) and TrkC (G,H,O,P) in situ hybridization of transverse sections through DRG of wild-type (WT) and Rbpj CKO mice at E11.5 and post natal day (P)0. Scale bars: 100 μm. (Q) At E11.5, TrkA⁺ neurons are significantly decreased in Rbpj CKO DRG and there are no significant differences in the number of SCG10⁺, TrkB⁺and TrkC⁺neurons between wild-type and Rbpj CKO mice. (R) The numbers of SCG10⁺, TrkA⁺and TrkB⁺neurons are significantly decreased, but that of TrkC⁺neurons is unchanged in Rbpj-deficient DRG relative to wild-type controls at P0. Error bars represent standard error of the mean; *P < 0.01.