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Figure 4 | Neural Development

Figure 4

From: Cortico-cerebral histogenesis in the opossum Monodelphis domestica: generation of a hexalaminar neocortex in the absence of a basal proliferative compartment

Figure 4

Dynamics of phospho-histone3 and Tbr2 expression in the developing opossum cortex. (A) Phospho-histone3 (pH3) immunoprofiling of mid-frontal neocortical sections of P1 to P25 opossums. Immunopositive cells are prevalently aligned near the ventricle; solid arrowheads point to rare abventricular pH3+ mitotic cells. (B) Diagrammatic representation of pH3+ cells sampled in (A). (C) Tbr2 immunoprofiling of mid-frontal neocortical sections of P1 to P18 opossums. (D-F). Linear densities (D) and radial distributions (F) of Tbr2+ cells sampled in (C). (E) Linear densities of Tbr2+ cells in the mouse. Grey, pink and green shading in (D, E) demarcate peak neuronogenesis windows for primordial plexiform layer (ppl), inner cortical plate (i-cp) and outer cortical plate (o-cp), respectively. Abbreviations: II-IV, V, VI refer to cortical layers; cp, cortical plate; e, ependyma; iz, intermediate zone; mz, marginal zone; ppl, preplate; se, subependymal zone; sp, subplate; vz, ventricular zone; wm, white matter. Scale bars: 100 μm in (A, C).

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Neural Development

ISSN: 1749-8104