Figure 5

Size lateralization is not activity dependent but developmentally programmed. (A) Measurements of ASEL and ASER soma volumes in worms with less neuronal activity. Neuronal activity was reduced either by hatching embryos into ddH2O and leaving them for approximately 16 hours (labeled starved) or by mutant analysis. Starved worms had to be measured as L1s, as the worms will not grow past the L1 stage in the absence of food. All others were measured as adults. Wild-type (WT) volumes are shown for comparison. Error bars are standard error of the mean (s.e.m.); *P < 0.05, **P < 0.01. (B) Measurements of ASEL and ASER volume sizes during development. Error bars are s.e.m.; **P < 0.01. (C) Measurement of ASEL and ASER volume sizes in a che-1 mutant. Error bars are s.e.m.; **P < 0.01. ns, not significant.