Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain

Table 4 Transcripts with brain expression were surveyed for evidence of gene association with neurocognitive disorders

Mouse gene	Human gene	Gene association with neurocognitive disorders	Chromosomal position	Autism endophenotype[37]
Pax7	PAX7		1p36.2-p36.12	Language, communication
Ncl	NCL		2q12-qter	Language, communication
Ctnnb1	CTNNB1	SZ [51] (protein level)	3p22-p21.3
Phox2b	PHOX2B	SZ [52], OMIM 603851	4p12
Pitx1	PITX1	ASD [53]	5q31
Ezh2	EZH2		7q35-q36	Language, communication; developmental regression
Ipmk	IPMK		10q21	Social responsiveness
Nkx2-3	NKX2-3		10q24.2	Social responsiveness
Pitx3	PITX3		10q25	Social responsiveness
Foxi2	FOXI2		10q26	Social responsiveness
Cux2	CUX2	BPD [54]	12q24.12
Nkx2-1	NKX2-1	MR [55], OMIM 600635	14q13
Tcfap4	TFAP4		16p13	Repetitive behavior/OCD; language, communication
Fox1	A2BP1	ASD [35], MR and seizures [36]	16p13.3	Repetitive behavior/OCD
Jup	JUP		17q21	Social responsiveness
Ezh1	EZH1		17q21.1-q21.3	Social responsiveness
Hnf4a	HNF4A		20q12-q13.1	Language, communication
Arx	ARX	ASD, MR, seizures [34], OMIM 300382	Xp22.13

Autism endophenotype data are reviewed in [37]. ASD, autism spectrum disorder; BPD, bipolar disorder; MR, mental retardation; OCD, obsessive-compulsive disorder; OMIM, Online Mendelian Inheritance in Man; SZ, schizophrenia.

ISSN: 1749-8104