Mouse gene | Human gene | Gene association with neurocognitive disorders | Chromosomal position | Autism endophenotype[37] |
---|---|---|---|---|
Pax7 | PAX7 | Â | 1p36.2-p36.12 | Language, communication |
Ncl | NCL | Â | 2q12-qter | Language, communication |
Ctnnb1 | CTNNB1 | SZ [51] (protein level) | 3p22-p21.3 | Â |
Phox2b | PHOX2B | SZ [52], OMIM 603851 | 4p12 | Â |
Pitx1 | PITX1 | ASD [53] | 5q31 | Â |
Ezh2 | EZH2 | Â | 7q35-q36 | Language, communication; developmental regression |
Ipmk | IPMK | Â | 10q21 | Social responsiveness |
Nkx2-3 | NKX2-3 | Â | 10q24.2 | Social responsiveness |
Pitx3 | PITX3 | Â | 10q25 | Social responsiveness |
Foxi2 | FOXI2 | Â | 10q26 | Social responsiveness |
Cux2 | CUX2 | BPD [54] | 12q24.12 | Â |
Nkx2-1 | NKX2-1 | MR [55], OMIM 600635 | 14q13 | Â |
Tcfap4 | TFAP4 | Â | 16p13 | Repetitive behavior/OCD; language, communication |
Fox1 | A2BP1 | 16p13.3 | Repetitive behavior/OCD | |
Jup | JUP | Â | 17q21 | Social responsiveness |
Ezh1 | EZH1 | Â | 17q21.1-q21.3 | Social responsiveness |
Hnf4a | HNF4A | Â | 20q12-q13.1 | Language, communication |
Arx | ARX | ASD, MR, seizures [34], OMIM 300382 | Xp22.13 | Â |