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Figure 3 | Neural Development

Figure 3

From: RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer

Figure 3

RBP-J deletion in granule neuron progenitors does not change cerebellar morphology. (A-L) Haematoxylin and eosin staining of brain sections at E18.5 (A-D), P7 (E-H) and P21 (I-L). Ptc1 deletion results in progressive thickening of the EGL and medulloblastoma formation by P21 (B,F,J), which is not ameliorated by RBP-J deletion (D,H,L). Cerebella of RBP-Jlox/lox;Math1-Cre mice (C,G,K) are undistinguishable from controls (A,E,I). Images in each panel were taken at the same magnification; scale bars represent 1 mm.

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Neural Development

ISSN: 1749-8104