Context-dependent functions of specific microRNAs in neuronal development

Table 2 mRNA targets and functions of miR-124 in neuronal development and function

Functions	Species	Targets	References
Inhibits long-term facilitation at the sensory-motor synapses	Aplysia	CREB	[45]
Suppresses dendritic branching by overexpression	D. melanogaster	?	[68]
Promotes neuronal differentiation in spinal cord	Chick	SCP1	[49]
Promotes neurite growth	P19 cells	RhoA	[71]
Involved in BAF53b-induced activity-dependent dendritic growth	Rodent	BAF53b	[73]
Promotes neuronal differentiation in developing brain	Rodent	REST, PTBP1, Ephrin-B1	[62–64]
Promotes adult neurogenesis	Rodent	Sox9	[65]
Promotes neuronal differentiation	Rodent	?	[58]
Cocaine-induced plasticity in the adult brain	Rodent	CREB, BDNF	[85]

BDNF, brain-derived neurotrophic factor; CREB, cAMP response element binding protein; PTBP1, polypyrimidine tract-binding protein 1; REST, RE1 silencing transcription factor; SCP1, small C-terminal domain phosphatase 1.

ISSN: 1749-8104