Figure 4

Long-term developmental exposure to TNF-α does not alter intrinsic membrane currents of tectal neurons. (A) Family of current traces recorded in response to a series of depolarizing steps from -60 to +30 mV. The fast inward current is a voltage-gated Na⁺ current while the outward current is a voltage-gated K⁺ current. (B) I-V curves for Na⁺ and K⁺ currents in control tectal cells and cells from TNF-α reared tadpoles. (C) Maximum peak amplitudes of Na⁺ and K⁺ currents from both groups show no significant differences. For P-values see Results. N.S., not significant.