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Figure 4 | Neural Development

Figure 4

From: FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm

Figure 4

Inhibition of Wnt signaling by DKK1 enhances the number of primitive and definitive neural stem cells in the neural plate. (A) Effect of inhibition of Wnt signaling on colony formation (three separate experiments; n = 2 to 3 embryos for each treatment group; three replicates per culture condition per treatment in each experiment). (B) Effect of SU5402 with or without DKK1 on colony formation (four separate experiments; n = 2 to 3 embryos for each treatment group; four replicates per culture condition per treatment in each experiment). *Statistical significance compared to the positive control dimethyl sulfoxide (DMSO)/PBS injected, FGF2 + heparin (H) cultured, P < 0.05; **statistical significance compared to DMSO/PBS injected, LIF cultured, P < 0.05. S.d., standard deviation.

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