Table 3 Summary of photoreceptor phenotypes associated with loss of Dynein1 or Dynactin
Genotype | Rounded nuclei | Cells lacking inner segments | Organelle position defects | Outer segment defects |
|---|---|---|---|---|
mok/dctn1a | Yes | No | Nuclei, mitochondria (mild) | Short OS |
dctn1a+1b MO | Yes | No | Nuclei, mitochondria, Golgi (mild) | Short OS |
cnb/dync1h1 | Yes | Yes | Nuclei, mitochondria, Golgi, centrioles (severe) | Short, disorganized OS prone to vesiculation, total lack of OS |
dync1h1 MO (high dose) | Yes | Yes | Nuclei, mitochondria, Golgi, centrioles (severe) | Short, disorganized OS prone to vesiculation, total lack of OS |
dync1h1 MO (low dose) | Yes | No | Mitochondria, Golgi, centrioles (mild) | Short, disorganized OS prone to vesiculation |