Figure 8

Knock-down of Dync1h1 phenocopies cnb mutants. (A-C) TEM of retinas from 3-dpf embryos injected with a high dose (8 ng/embryo) of dync1h1 morpholino (MO). Photoreceptors across the entire retina failed to form outer segments and had rounded nuclei (N). (D-L) TEM views of embryos injected with a lower amount (3 ng/embryo) of dyn1 hc1 morpholino. Outer segments formed in some photoreceptors at the central (D, E) and peripheral retina (F) (arrows). Most lower dose morphant cells still failed to elongate outer segments. Scale bars: 10 μm in (A-E); 2 μm in (F).