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Figure 2 | Neural Development

Figure 2

From: Pharmacological manipulation of GABA-driven activity in ovo disrupts the development of dendritic morphology but not the maturation of spinal cord network activity

Figure 2

Role of GABAergic neurotransmission on the generation of network activity in the E8 and E10 chicken spinal cord. (A, B) Effect of bicuculline on the generation of network activity in the E8 chicken spinal cord. Network activity in the E8 chicken spinal cord was completely eliminated by treatment with 10 μM of bicuculline. Notice that activity recovers following washout of bicuculline. (B) Data showing the effect of bicuculline on the inter-episode interval and episode duration in E8 chicken spinal cords (n = 4). After washout of bicuculline from the bathing solution, the inter-episode interval and episode duration recovers to control levels. (C, D) Network activity in the E10 chicken spinal cord was completely eliminated by treatment with 10 μM of bicuculline. After washout of bicuculline, activity recovers to control levels. (D) Time-dependent effect of bicuculline (Bic) on the inter-episode interval in an E10 spinal cord. Notice that application of bicuculline for 30 minutes causes a complete cessation of network activity, which tends to recover to control levels after removal of bicuculline from the bathing solution.

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Neural Development

ISSN: 1749-8104