Figure 7

Schematic diagram of facial branchiomotor (FBM) migration and signalling pathways. (A) Schematic diagrams of the final position of the FBM nucleus in embryonic stage (E)14.5 mouse embryos of wild-type, and Wnt5a, Vangl2/Scribble and Fz3 mutant mice. Red patches represent facial nuclei at their final location in wild-type or mutant background. Grey patches show trigeminal nuclei. The red arrow shows the direction of FBM migration in wild-type; the dashed red arrow represents a partial loss of migration in the Wnt 5A^-/- mutant; crossed red arrow represents a total loss of migration in the Vangl2/Scrb^-/- mutant; the crossed red dashed arrow indicates a loss of migration and partial lateral FBM migration in r5 and r6 in the Fz3^-/- mutant. The violet gradient represents the putative distribution of Wnt 5A protein. FP, floor plate. (B) Schematic diagrams of putative Wnt signalling pathways to the cytoskeleton in FBM neurons. Dvl, Dishevelled; Fz, Frizzled; JNK, c-Jun amino-terminal kinase; MLCK, myosin light chain kinase; Pk, Prickle; ROCK, Rho kinase; Scrb, Scribble; Stbm, Strabismus; Vangl2, Van Gogh-like 2.