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Figure 2 | Neural Development

Figure 2

From: Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex

Figure 2

Rostral shift of cortical areas in Foxg1-Cre;Fgfr3+/K644M. (a, b) Formation of the cortical areas was analyzed in the flattened cortex of Foxg1-Cre;Fgfr3+/K644M(b) and control (a) at P6.5 by cytochrome C oxidase histochemistry. (c-e) Measurements show an increase in total and occipital lengths of the cortex, while the frontal length remained similar. (f, g) The F/T and O/T length ratios clearly show that the PMBSF was rostrally shifted in Foxg1-Cre;Fgfr3+/K644M. (h-j) The lateral length of the cortex was increased in Foxg1-Cre;Fgfr3+/K644Mcompared to control, while no significant difference was observed in the total and medial lengths. (k, l) The L/W ratio shows that the PMBSF was medially shifted in Foxg1-Cre;Fgfr3+/K644M. Scale bar: 1 mm in (a, b).

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