Figure 3

Models for Notch activity in binary decisions. Cells have the choice between two subtype identities, the A fate (in red) and B fate (in green), which can be induced by an A-inducing signal (in red) or a B-inducing signal (in green). (A-D) Notch activity (in pink) influences cell fate either by inhibiting the B fate (A, B, D) or by activating the A fate (C). In the epiphysis (A), Loss of Notch activity (LOF) results in the production of AB cells (yellow) while gain of Notch activity (GOF) results in the production of neurons with no identity (blue). (E) Notch regulates the competence to respond to a second signalling pathway.