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Figure 5 | Neural Development

Figure 5

From: The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding

Figure 5

Pan-neuronal Elav-Gal4 overexpression of the diffusible turtle isoform AT02763 promotes neuronal invasiveness. (A) Representation of the major histological divisions of the adult fly nervous system in the head (LA, lamella; LO, lobula; MD medulla). (B) Wild-type head horizontal section, stained with the nuclear marker DAPI (blue fluorescence), showing the peripheral location of the cortex (arrow) and the central location of DAPI-free neuropil (asterisk). (C) Adult horizontal section stained with the neuronal marker Elav (green fluorescence), showing that most of the cortex is composed of neuronal cells (arrow). (D) Pan-neuronal overexpression of the diffusible isoform AT02763 produces cells that invade the normally cell-free neuropil layer (arrowhead)s. (E) Most of these invasive cells are Elav-positive neurons (arrowhead).

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