Mathematical modeling supports substantial mouse neural progenitor cell death

Table 1 Model parameters and constraints

Parameter	Symbol	Values	References
Founding NPC population	P ₀	5 to 6 × 10⁵	[15, 16]
NPC CC number	i	1 to 11	[6]
Fraction of NPCs that become newly	q _i	q₁ = 0.005; q₂ = 0.04;	[14, 37]
post-mitotic neurons		q₃ = 0.09;q₄ = 0.14;
		q₅ = 0.21;q₆ = 0.31;
		q₇ = 0.42; q₈ = 0.54;
		q₉ = 0.69;q₁₀ = 0.84;
		q₁₁ = 1.0
Fraction of NPCs that die at i^thCC	d _i	5% to >50%	[12, 13, 17]
After i^thCC, number of new:
Post-mitotic cells	Q_I	Model specific,
NPCs	P_I	see text
Dying daughter cells	D_I
Total neurons produced from NPCs		1 × 10⁷ to 2.72 × 10⁷	See text
	VZ output
Cortical neurons		10 to 16 × 10⁶	[53, 54]
Cortical interneurons		15 to 30% of cortical neurons	[20, 24, 35]
Post-natal cell death		30 to 50% of cortical neurons	[20, 24, 55]
Fraction of IPCs at each CC	q' _i	q'₁ = 0; q'₂ = 0; q'₃ = 0;	[10, 12, 13]
		q'₄ = 0; q'₅ = 0.12;
		q'₆ = 0.12; q'₇ = 0.16;
		q'₈ = 0.16; q'₉ = 0.54;
		q'₁₀ = 0.54; q'₁₁ = 0.54

ISSN: 1749-8104