Figure 5

Constrained models require substantial levels of progenitor cell (NPC) death. Ventricular zone (VZ) output as plotted in Figure 1, including intermediate progenitor cells (IPCs) as in model D_G1 (Figure 3A) and model D_G2 (Figure 3B). (A, B) After three expansion cell cycles (CCs) the plausibility window is centered at 33% using model D_G1 (A) and 33% using model D_G2 (B). (C, D) After four expansion CCs the plausibility window is centered at 42% using model D_G1 (C) and 39% using model D_G2 (D). (E, F) After five expansion CCs the plausibility window is centered at 59% using model D_G1 (E) and 47% using model D_G2 (F).