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Figure 8 | Neural Development

Figure 8

From: Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice

Figure 8

Aberrant corticothalamic projections in conditional knockouts. (A) Coronal section of E14.5 conditional knockout (cKO) cortex following injection of DiI in dorsal thalamus: retrogradely labeled cell bodies are visible, some are indicated by arrows. (B) Diagram of the forebrain showing sites of cortical injection of DiI (red in visual area 1 (V1)) and DiA (green in somatosensory area 1 (S1)). (C, D) Control E16.5 brains showing (C) DiI and (D) DiA label in the internal capsule (IC). (E, F) E16.5 cKO brains showing (E) DiI and (F) DiA label in the internal capsule; some aberrant DiI label from V1 was also seen traveling laterally (white arrowhead in (E)). (G, G') E16.5 cKO brains showing higher magnification of area indicted by the white arrowhead in (E): many labeled axons (arrowheads) are seen projecting to the pial surface. Scale bars: 50 μm.

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