Figure 5

Schematic illustration of Sema5B function at synapses. Cells expressing high Sema5B levels exhibit fewer presynaptic inputs (b) compared to wild type cells (a). Consistent with these observations, a reduction in Sema5B levels results in a significant increase in the number of presynaptic inputs and the size of both pre and postsynaptic compartments (c). In contrast, the number of synapses made by cells expressing high levels of Sema5B (e) is similar to wild type cells (d).