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Figure 11 | Neural Development

Figure 11

From: Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis

Figure 11

Nlg PDZ binding motif is important for co-transport of Nlg1 and NMDA receptors. (A) Time-lapse imaging of neurons co-transfected with either GFP-Nlg1 (green, left panel) and NR1-DsRed (red), or GFP-NlgΔC4 (green, right panel) and NR1-DsRed (red). Arrowheads indicate colocalized Nlg1 and NR1 clusters. Scale bar, 5 μm. (B) Fluorescence intensity profiles (in arbitrary units (a.u.)) along a line drawn through the dendrite, between the white faded lines shown in (A, top panels). Boxed regions around fluorescent intensity peaks correspond to colocalization of Nlg and NR1. (C) Deletion of the PDZ binding motif within the cytoplasmic tail of Nlg significantly reduced the colocalization of total and mobile Nlg clusters with NR1. Error bars are standard error; *P ≤ 0.001.

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