Figure 4
From: Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
Retinal ganglion cells (RGCs) are overproduced in the Ccnd1-/- retina. (A-H) Wild-type (wt) and Ccnd1-/- retinas were stained with an antibody against POU4F2, which marks a majority of RGCs, at E11, E12, E14.5 and P0. Arrows in (H) mark the extra layer of RGCs in the Ccnd1-/- retina at P0. (I) Quantification of relative proportions of POU4F2+ RGCs. (J) Quantification of relative rate of POU4F2+ RGC production between E13.5 to E14.5. Abbreviations: DCL, differentiated cell layer; L, lens; NBL, neuroblast layer; NR, neural retina. Scale bars: 100 μm; (G) is representative for (C, G); (H) for (A, B, D, E, F, H).