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Table 4 Pioneer and interneuron defects in IgCAM mutants

From: IgCAMs redundantly control axon navigation in Caenorhabditis elegans

Gene

VC entry

Inter-neuron

AVG

PVPL

PVQR

PVPR

PVQL

Wild type

       

   rhIs4 hdIs26

1

6

0

0

0

7

9

Single mutants

       

   rig-1(hd15) X

2

14

0

0

0

4

4

   rig-3(hd51) X

0

4

0

0

0

9

9

   rig-4(hd47) IV

0

0

0

0

0

7

7

   rig-5(hd48) I

0

4

0

0

1

9

9

   rig-6(gk376) II

1

6

0

0

0

7

7

   rig-6(ok1589) II

0

1

0

0

0

5

5

   syg-1(hd18) X

1

6

0

0

0

6

6

   wrk-1(hd45) X

1

16†

0

0

0

34*

36*

   ncam-1(hd49) X

1

5

0

1

1

12

12

Multiple mutants

       

   rig-6 II; rig-4 IV; syg-1 X

0

4

0

1

1

11

10

   rig-4 IV; syg-1 wrk-1 X

2

9

0

4†

4†

35*

35*

   rig-6 II; syg-1 wrk-1 X

6

11

0

3

3

40*

40*

   rig-6 II; rig-4 IV; syg-1 wrk-1 X

1

18†

0

1

3

34*

35*

   rig-5 I; rig-6 II; rig-1 X

5

12

0

0

1

8

8

   rig-5 I; rig-6 II; rig-3 X

2

6

0

0

0

4

4

   rig-5 I; rig-1 rig-3 X

7†

10

0

0

0

7

7

   rig-6; rig-1 rig-3 X

4

8

0

0

0

6

6

   rig-5 I; rig-6 II; rig-1 rig-3 X

4

30*

1

1

1

16†

14

   rig-5 I; rig-6 II; rig-4 IV; rig-1 wrk-1 rig-3 syg-1 ncam-1 X

6

37*

0

0

2

48*

48*

  1. Alleles used were: syg-1 (hd18); wrk-1 (hd45); ncam-1 (hd49); rig-1 (hd15); rig-3 (hd51); rig-4 (hd47); rig-5(hd48); rig-6(gk376). All defects are ventral cord cross-over defects. VC entry: failure of axons to cross to right side upon ventral cord entry (rhIs4). Interneuron: glr-1::GFP expressing interneurons. n = 100, numbers in table are percent of animals with defects. *Significant with p < 0.01; †significant with p < 0.05; χ2 test.