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Figure 4 | Neural Development

Figure 4

From: IgCAMs redundantly control axon navigation in Caenorhabditis elegans

Figure 4

Neuronal defects in IgCAM mutants. Wild type is on the left and defects in rig-5 I; rig-6 II; rig-4 IV; rig-1 wrk-1 rig-3 syg-1 ncam-1 X mutant animals are shown on the right. Defects are indistinguishable from the defects seen in the single mutants and, therefore, representative of single mutants as well. Anterior is to the left. Scale bar: 10 μm. (A-D) DD/VD motoneurons (A-B ventral view, C-D lateral view). (E, F) DA/DB motoneurons, ventral view. (G, H) glr-1::GFP expressing interneuron axons. (I, J) PVP/AVG. (K, L) PVQ axons, same animal as in (I-J). Defects consist of axons extending in the left ventral cord tract (arrowhead in (B)), commissures growing on the left rather than the right side (small arrow in (B)), misplaced motoneuron cell bodies located outside the ventral cord region (large arrows in (B)), commissures not reaching the dorsal cord (small arrow in (D)), DA2/DB3 commissures growing on the left rather than the right side (arrow in (F)), interneuron axons crossing between left and right axon tracts (arrowheads in (H)), and PVPR and PVQL axons crossing into the right axon tract (arrowheads in (I, L)).

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