Figure 7

Model to depict Fak56 and ERK signaling and Fasciclin II (FasII) protein levels at neuromuscular junctions (NMJs). In restricting NMJ growth, the extracellular matrix signal laminin including the α subunit LanA is received by integrin receptors, including αPS3 and βν subunits. This signal is transduced through the association between Fak56 and Src, and in this process phosphorylation of Y430 Fak56 is essential. Activated Fak56 mediates signaling through suppressing ERK activation at NMJs and consequently upregulates the FasII protein level at NMJs, leading to the inhibition of NMJ growth. Those molecules (shown in grey) were not tested in this study.