Figure 3

Role of Src and its genetic interaction with Fak56 during neuromuscular junction (NMJ) growth. (A-D) Images of NMJ 6/7 are shown as in Figure 1. Fak56^{N 30/KG}mutants carrying one allele of Src42A^{E 1}(A) or Src64B^PI(B) displayed NMJ overgrowth phenotype. (C) NMJ phenotype in the severe Src mutant Src42A^{E 1/+};Src64B^PI/PI. (D) NMJ phenotype of the Fak56^{N 30/K 24}null mutant was enhanced by removing both one Src42A^{E 1}and one Src64B^PIallele. (E) Quantification of NMJ 6/7 phenotypes for Fak56^{N 30/KG}(the same set of data as in Figure 2G), Src42A^{E 1/+}Fak56^{N 30/KG}, Fak56^{N 30/KG};Src64B^PI/+, Src42A^{E 1/+}, Src42A^{E 1/+};Src64B^PI/+and Src42A^{E 1/+};Src64B^PI/PI. Note that Src42A^{E 1/+}and Src42A^{E 1/+};Src64B^PI/+show no significant alteration in NMJ phenotypes when compared to wild-type. Asterisks indicate significant difference by Student's t test (p < 0.05) and error bars represent the standard error of the mean (SEM).