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Figure 6 | Neural Development

Figure 6

From: A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction

Figure 6

Morphological defects in nid2-/- neuromuscular junctions (NMJs) are due to improper maturation and maintenance. (A, B) NMJs from diaphragms of P7 (A) and P21 (B) nid2-/- mutants and aged-matched controls. Pre- and postsynaptic elements are labeled with anti-synaptotagmin 2 antibodies (syt 2) and α-bungarotoxin (BTX), respectively. No obvious defects were present at either age. (C) NMJs from diaphragms of 1-year-old mutants and age-matched controls. Mutant NMJs were fragmented at 1 year of age but were not appreciably more severely affected than in 2-month-old mutants (Figure 5). Scale bars are 20 μm.

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