Figure 10
From: A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction
Synaptic localization of laminins, collagens IV and agrin occurs independently of other major basal lamina (BL) components. (A-G) In addition to nidogen-2 (Figure 9) other components of synaptic BL were examined in mutant mice lacking all four synaptic collagen IV chains (col4a5-/Y) (A-D) and collagen α3(IV) in laminin β2 (lamb2-/-) (E), laminin α4 (lama4-/-) (F) and laminin α5 (lama5M/M:HAS-Cre) (G) mutants. In the absence of any synaptic BL component, other families of BL molecules remained properly enriched at synaptic sites. Scale bar is 5 μm.