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Figure 9 | Neural Development

Figure 9

From: The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter

Figure 9

Met signaling may influence CaP axonal and neurotransmitter phenotypes through the MEK1/2 pathway. All panels show mn2Et transgenic embryos. (a-d") Embryos at 26 hpf showing GFP (green) and GABA (red); asterisks indicate CaPs or CaP/VaP pairs. (a',b',c',d') Only the green channel is shown; (a",b",c",d") only the red channel of the micrographs shown in (a,b,c,d) is shown. CaPs express GABA in U0126-treated embryos (c-c") and met MO-injected embryos (b-b") but not in controls (a-a") or in SB203580-treated embryos (d-d"). (e-h) Some CaPs have both peripheral (arrows) and central (asterisks) axons in U0126-treated embryos (g) and met MO-injected embryos (f); CaPs have only have peripheral axons in controls (e) and in SB203580-treated embryos (h). Scale bars, 10 μm.

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