Figure 8
From: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
Model of genetic interactions upstream and downstream of Fgf15 and Fgf8 within embryonic telencephalon. Shh promotes Fgf15 expression (Addition file 2) [6, 20, 35], and maintains Fgf8 expression [68]. Fgf8 is required for Shh induction [22]. Fgf15 activates, whereas Fgf8 represses, expression of CoupTF1 (among other genes), which represses proliferation and promotes differentiation and caudal fate [37, 38].