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Table 2 Increased transcripts in the DRG of Brn3a knockout mouse

From: POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

Transcript

Symbol

Class

WT

HT

KO

KO/WT

Chordin-like 1

Chrdl1

Dev

5

2

134

27.4

Musculin (MyoR)

Msc

TX

211

675

1,260

6.0

Insulinoma-associated 1

Insm12

TX

153

301

827

5.4

GABA transporter 1 (Gabt1)

Slc6a1

NT

74

93

397

5.3

Microfibrillar-associated 4

Mfap4

Unk

112

370

559

5.0

Secretogranin II

Scg2

SY

206

253

966

4.7

C-fos induced growth factor (VEGF-D)

Figf

Dev

76

102

319

4.2

Guanylate cyclase 1, alpha 3

Gucy1a3

ST

50

82

205

4.1

Neurogenic differentiation 6 (Math2, Nex)

Neurod6

TX

83

200

344

4.1

Somatostatin

Sst

NT

215

382

830

3.9

Neurexin III

Nrxn34

SY

367

961

1,412

3.8

Bruno-like 4

Brunol43

Other

154

274

588

3.8

Cell adhesion molecule with homology to L1CAM

Chl1

AX

128

127

466

3.6

Junctophilin 1

Jph1

Other

74

119

262

3.5

Glutamate receptor, ionotropic, AMPA4

Gria43

NT

46

80

161

3.5

Glutamate receptor, ionotropic, AMPA3

Gria3

NT

40

66

138

3.5

Zinc finger homeobox 1b

Zfhx1b2

TX

81

127

270

3.3

Nel-like 2

Nell2

AX

383

331

1,215

3.2

Follistatin-like 5

Fstl52

Dev

281

389

885

3.2

Disabled homolog 1

Dab12

AX

90

42

272

3.0

Mannan-binding lectin serine protease 1

Masp1

Other

95

101

282

3.0

Selected

      

Semaphorin 3C

Sema3c2

AX

589

723

1,732

2.9

Cholecystokinin A receptor

Cckar

NT

95

161

269

2.8

Serotonin receptor 3A

Htr3a

NT

778

1,160

2,090

2.7

Homeobox A5

Hoxa5

TX

628

896

1,493

2.4

Neurogenic differentiation 1

Neurod12

TX

1,048

1,468

2,440

2.3

p21-activated kinase 3

Pak32

SY

246

270

568

2.3

Semaphorin 3D

Sema3d

AX

318

365

725

2.3

Protocadherin 17

Pcdh172

AX

331

340

746

2.3

Spondin 1, (f-spondin)

Spon1

AX

629

778

1,413

2.2

K+ voltage-gated channel, Isk family

Kcne1l

NT

613

813

1,328

2.2

Deleted in colorectal carcinoma

Dcc

AX

93

101

200

2.2

Netrin G1

Ntng1

AX

388

556

812

2.1

Neuropilin 2

Nrp2

AX

509

485

1,063

2.1

Cadherin 22

Cdh22

AX

199

226

414

2.1

Synapsin II

Syn24

SY

643

688

1,324

2.1

Glutamate receptor, ionotropic, kainate 1

Grik1

NT

221

241

455

2.1

Protocadherin 8

Pcdh82

AX

278

398

569

2.0

GDNF receptor alpha 2

Gfra2

Dev

363

436

735

2.0

Nescient helix loop helix 2 (Nscl2)

Nhlh2

TX

1,222

1,996

2,446

2.0

  1. Data for one of two independent experiments are shown. All listed transcripts showed increased expression (change p < 0.005) in two independent replicates. Data are complete for all replicated changes above three-fold, and selected data appear for transcripts exhibiting two- to three-fold change. A full data set appears in Additional file 1. Superscript numerals represent the number of probe sets concordant for changed expression for a given gene. AX, neurogenesis/axon growth and guidance; Dev, development; KO, knockout; NT, neurotransmission; ST, signal transduction; SY, synapse formation and function; TX, transcription; Unk, unknown; WT, wild type.