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Table 2 Increased transcripts in the DRG of Brn3a knockout mouse

From: POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

Transcript Symbol Class WT HT KO KO/WT
Chordin-like 1 Chrdl1 Dev 5 2 134 27.4
Musculin (MyoR) Msc TX 211 675 1,260 6.0
Insulinoma-associated 1 Insm12 TX 153 301 827 5.4
GABA transporter 1 (Gabt1) Slc6a1 NT 74 93 397 5.3
Microfibrillar-associated 4 Mfap4 Unk 112 370 559 5.0
Secretogranin II Scg2 SY 206 253 966 4.7
C-fos induced growth factor (VEGF-D) Figf Dev 76 102 319 4.2
Guanylate cyclase 1, alpha 3 Gucy1a3 ST 50 82 205 4.1
Neurogenic differentiation 6 (Math2, Nex) Neurod6 TX 83 200 344 4.1
Somatostatin Sst NT 215 382 830 3.9
Neurexin III Nrxn34 SY 367 961 1,412 3.8
Bruno-like 4 Brunol43 Other 154 274 588 3.8
Cell adhesion molecule with homology to L1CAM Chl1 AX 128 127 466 3.6
Junctophilin 1 Jph1 Other 74 119 262 3.5
Glutamate receptor, ionotropic, AMPA4 Gria43 NT 46 80 161 3.5
Glutamate receptor, ionotropic, AMPA3 Gria3 NT 40 66 138 3.5
Zinc finger homeobox 1b Zfhx1b2 TX 81 127 270 3.3
Nel-like 2 Nell2 AX 383 331 1,215 3.2
Follistatin-like 5 Fstl52 Dev 281 389 885 3.2
Disabled homolog 1 Dab12 AX 90 42 272 3.0
Mannan-binding lectin serine protease 1 Masp1 Other 95 101 282 3.0
Selected       
Semaphorin 3C Sema3c2 AX 589 723 1,732 2.9
Cholecystokinin A receptor Cckar NT 95 161 269 2.8
Serotonin receptor 3A Htr3a NT 778 1,160 2,090 2.7
Homeobox A5 Hoxa5 TX 628 896 1,493 2.4
Neurogenic differentiation 1 Neurod12 TX 1,048 1,468 2,440 2.3
p21-activated kinase 3 Pak32 SY 246 270 568 2.3
Semaphorin 3D Sema3d AX 318 365 725 2.3
Protocadherin 17 Pcdh172 AX 331 340 746 2.3
Spondin 1, (f-spondin) Spon1 AX 629 778 1,413 2.2
K+ voltage-gated channel, Isk family Kcne1l NT 613 813 1,328 2.2
Deleted in colorectal carcinoma Dcc AX 93 101 200 2.2
Netrin G1 Ntng1 AX 388 556 812 2.1
Neuropilin 2 Nrp2 AX 509 485 1,063 2.1
Cadherin 22 Cdh22 AX 199 226 414 2.1
Synapsin II Syn24 SY 643 688 1,324 2.1
Glutamate receptor, ionotropic, kainate 1 Grik1 NT 221 241 455 2.1
Protocadherin 8 Pcdh82 AX 278 398 569 2.0
GDNF receptor alpha 2 Gfra2 Dev 363 436 735 2.0
Nescient helix loop helix 2 (Nscl2) Nhlh2 TX 1,222 1,996 2,446 2.0
  1. Data for one of two independent experiments are shown. All listed transcripts showed increased expression (change p < 0.005) in two independent replicates. Data are complete for all replicated changes above three-fold, and selected data appear for transcripts exhibiting two- to three-fold change. A full data set appears in Additional file 1. Superscript numerals represent the number of probe sets concordant for changed expression for a given gene. AX, neurogenesis/axon growth and guidance; Dev, development; KO, knockout; NT, neurotransmission; ST, signal transduction; SY, synapse formation and function; TX, transcription; Unk, unknown; WT, wild type.
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Neural Development

ISSN: 1749-8104