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Figure 6 | Neural Development

Figure 6

From: Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans

Figure 6

Model for calcium channel function and OLRN-1 in the AWCON/AWCOFFdecision. All genes are expressed both in the left and in the right AWCs; color is used to indicate the cell in which each gene product is more active. The future AWCOFF transmits a signal to AWCON via NSY-5 gap junctions between AWC and other cells and NSY-4 claudins. This signal might be membrane potential. In AWCON, the signal suppresses the UNC-2 (CaV2) and EGL-19 (CaV1) voltage-activated calcium channels and allows high OLRN-1 activity. OLRN-1 inhibits the UNC-43 (CaMKII)/NSY-1/SEK-1 kinase cascade cell-autonomously within AWCON. A feedback signal from the calcium channels and OLRN-1 is transmitted from AWCON back to AWCOFF.

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Neural Development

ISSN: 1749-8104